Gastro-retention is essential for drugs that are absorbed from the stomach, drugs that are poorly soluble or degraded\nby the higher pH of intestine and drugs with an absorption which can be modified by changes in gastric emptying time. Floating\ndrug delivery systems are those systems having a bulk density less than that of the gastric fluids and remain buoyant for a\nprolonged period of time in the stomach without being affected by the gastric emptying rate. This work is concerned with the\nformulation and in-vitro evaluation of floating tablets of an antidiabetic drug. Vildagliptin is an oral anti-hyperglycemic agent\n(anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. The objective of this study was to\nimprove the bioavailability of the drug with reduction in dosing frequency and side effects. The tablets were prepared by using\nwet granulation method. Nine formulations were developed with different polymers like xanthan gum, poly ethyleneoxide and\nHPMC K15M. FTIR studies showed no evidence on interaction with drug, polymers and excipients. The prepared tablets were\nevaluated in terms of their precompression parameters, physical characteristics, in-vitro release, buoyancy lag-time and swelling\nindex. The in-vitro drug release profiles showed that formulation (F9) exhibited 99.97% drug release at the end of 24 hours. The\nin-vitro release kinetics reveals that the formulation (F9) follows zero order and the mechanism of drug release was non-fickian.
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